Research projects in SCN2A from around the world have been collated here.
Using computational analysis common symptoms for 5 phenotypes of SCN2A were found. The model also predicted gain & loss of function variants.
SCN2A severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors
This study showed a direct relationship between autism behaviour and SCN2A loss of function mutation in a mouse model.
This study found behaviour abnormalities in SCN2A mouse models that can be used to assess the effectiveness of new treatments.